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bio-clinical-databases-somatic-signatures

Extracts and assigns COSMIC v3.4 mutational signatures (86 SBS / 11 DBS / 18 ID / 21 CN / 16 SV) from somatic VCFs usin…

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Open / InstallLast updated July 27, 2026

Description

Extracts and assigns COSMIC v3.4 mutational signatures (86 SBS / 11 DBS / 18 ID / 21 CN / 16 SV) from somatic VCFs using SigProfilerSuite, MutationalPatterns, MuSiCal mvNMF, SigNet, or HRDetect. Use when characterizing DNA-damage etiology (BRCA1/2 HRD, MMR-D, POLE, APOBEC3A, UV, tobacco, aflatoxin, 5-FU/SBS17b, platinum, colibactin SBS88), routing PARP inhibitor decisions, or auditing de novo extraction vs refit choice for cohort size. A reusable SKILL.md agent skill by GPTomics.

Author

GPTomics

Platform

cli

Pricing model

free

Categories

Skills

Tags

skill
claude-skill
github
en

Capabilities

  • 1,053 stars
  • SKILL.md package