bio-clinical-databases-tumor-mutational-burden
Calculates tumor mutational burden from WES/WGS/panel data with Friends of Cancer Research harmonization equations, per…
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Open / InstallLast updated July 27, 2026
Description
Calculates tumor mutational burden from WES/WGS/panel data with Friends of Cancer Research harmonization equations, per-assay calibration (FDA 10/Mb = 7.8 TSO500 = 8.4 OncomineTML), synonymous/indel/germline filtering, hypermutator tiering, blood TMB, and integration with HLA-LOH and neoantigen quality (Luksza 2017 fitness). Use when assessing ICI eligibility under tumor-specific cutoffs (McGrail 2021), comparing tissue vs bTMB, or auditing TMB-H reporting against ESMO 2024 and FDA pembrolizumab pan-tumor 2020. A reusable SKILL.md agent skill by GPTomics.
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Author
GPTomics
Platform
cli
Pricing model
free
Categories
- Skills
Tags
- skill
- claude-skill
- github
- en
Capabilities
- 1,053 stars
- SKILL.md package
Information
TypeSkill
SourceSkillsmp
AddedJuly 27, 2026