TESSA (TCR and Expression Joint Clustering) is a Bayesian model that integrates T-cell receptor (TCR) sequence profilin…
TESSA (TCR and Expression Joint Clustering) is a Bayesian model that integrates T-cell receptor (TCR) sequence profiling with transcriptomes of T cells. It maps the functional landscape of the TCR repertoire by learning unified representations across modalities. The process employs BriseisEncoder to capture TCR sequence features, creating numerical embeddings that reconstruct Atchley Factor matrices and CDR3 sequences.
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